梁平

教育背景2005.09-2010.06，北京大学，神经科学，博士（导师：王克威教授）2008.01-2009.01，加州大学戴维斯分校，生理与膜生物学，访问学者（导师：郑劼教授）2000.09-2005.06，中国医科大学，临床医学，学士  工作经历2014.04-至今，浙江大学转化医学研究院，教授2011.05-2014.04，斯坦福大学，心血管研究所，博士后（导师：Joseph Wu教授）2010.09-2011.04，百泰生物药业有限公司，医学研发部，项目经理主要学术成绩主要致力于应用“病人特异性”iPSC来源的心肌细胞（iPSC-CM）进行心血管疾病研究，特别擅长于应用膜片钳电生理，并结合功能性细胞内钙成像检测、分子生物学、生物化学、细胞生物学、生物物理等多种功能学检测技术，进行重大、复杂性心律失常病（携带离子通道基因突变）、遗传性心肌病等疾病的分子和细胞机制研究、以及药物筛选。代表性论文发表在Cell Stem Cell、Circulation、JACC、Circulation Research、JMCC等杂志；合作论文发表在Science Translational Medicine、JACC、Circulation Research、PNAS、Journal of Neuroscience等杂志。代表性论文Tang L*, Wang H*, Dai B, Wang X, Zhou D, Shen J, Guo F, Wang J, Zhou J, Wang H, Wu Q, Yao H, Gong T, Su J, Meng Z#, Niu T#, Zhang L#, Liang P#. Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGFβ signaling in type 2 diabetes. JMCC 2020; 142: 53-64（*共同第一作者）（#共同通讯作者）Guo F*, Sun Y*, Wang X, Wang H, Wang J, Gong T, Chen X, Zhang P, Su L, Fu G, Su J, Yang S, Lai R, Jiang C#, Liang P#. Patient-specific and gene-corrected induced pluripotent stem cell-derived cardiomyocytes elucidate single-cell phenotype of short QT syndrome. Circulation Research 2019; 124 (1): 66-78（*共同第一作者）（#共同通讯作者）Tang L, Fang Yao F, Wang H, Wang X, Shen J, Dai B, Wu H, Zhou D, Guo F, Wang J, Li T, Wang H, Gong T, Su J#, Wang L#, Liang P#. Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes. JMCC 2018; 126: 143-154（#共同通讯作者）Liang P*#, Sallam K*, Wu H*, Li Y, Itzhaki I, Garg P, Zhang Y, Vermglinchan V, Lan F, Gu M, Gong T, Zhuge Y, He C, Ebert AD, Sanchez-Freire V, Churco J, Hu S, Sharma A, Lam CK, Scheinmman MM, Bers DM, Wu JC#. JACC 2016; 68 (19): 2086-2096（*共同第一作者）（#共同通讯作者）Wang Y*, Liang P*, Lan F*, Wu H*, Lisowski L, Gu M, Hu S, Kay M, Urnov F, Shinnawi R, Gold J, Gepstein L, Wu JC. Genome editing of isogenic human induced pluripotent stem cells recapitulates Long QT phenotype for drug testing. JACC 2014; 64 (5): 451-9（*共同第一作者）Navarrete EG*, Liang P*, Lan F*, Sanchez-Freire V, Simmons CS, Gong T, Sharma A, Burridge PW, Patlolla B, Lee AS, Beygui RE, Bers DM, Wu JC. Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation 2013; 128: S3-S13（*共同第一作者）Liang P*, Lan F*, Lee AS*, Gong T, Sanchez VF, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC. Drug screening using a library of human induced pluripotent stem cell derived cardiomyocytes reveals disease specific patterns of cardiotoxicity. Circulation 2013; 127 (16): 1677-1691 (由Dan Roden和Charles Hong配发评论) (2013 年度基础研究领域最佳论文)（*共同第一作者） Lan F*, Lee AS*, Liang P*, Sanchez VF, Nguyen PK, Wang L, Han L, Yen M, Wang Y, Sun N, Abilez OJ, Hu S, Ebert AD, Navarrete EG, Simmons CS, Wheeler M, Pruitt B, Lewis R, Yamaguchi Y, Ashley EA, Bers DM, Robbins RC, Longaker MT, Wu JC. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell 2013; 12 (1): 101-13 (Faculty 1000推荐“必读”文章)（*共同第一作者）